Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells.

BACKGROUND: Pancreatic cancer is one of the deadliest cancers with a 5-year survival rate of 6%. Therapeutic options are very limited and there is an unmet medical need for safe and efficacious treatments. Cancer cell metabolism and mitochondria provide unexplored targets for this disease. We recent...

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Bibliographic Details
Main Authors: Yumna H Shabaik, Melissa Millard, Nouri Neamati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3549929?pdf=render