Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence

Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence

In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encoded by Tnfsf11. Tnfsf11 mRNA increases in cortical...

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Bibliographic Details
Main Authors: Ha-Neui Kim, Jinhu Xiong, Ryan S. MacLeod, Srividhya Iyer, Yuko Fujiwara, Keisha M. Cawley, Li Han, Yonghan He, Jeff D. Thostenson, Elisabeth Ferreira, Robert L. Jilka, Daohong Zhou, Maria Almeida, Charles A. O’Brien
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-10-01
Series:JCI Insight
Subjects:
Bone biology
Online Access:https://doi.org/10.1172/jci.insight.138815

Internet

https://doi.org/10.1172/jci.insight.138815

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