VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy

VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy

Abstract Background The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy. However, viral integration has associated risks, such as the unintentional activation of oncogenes that can result in cancer. Therefo...

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Bibliographic Details
Main Authors: José M. Juanes, Asunción Gallego, Joaquín Tárraga, Felipe J. Chaves, Pablo Marín-Garcia, Ignacio Medina, Vicente Arnau, Joaquín Dopazo
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Bioinformatics
Subjects:
Gene therapy
Viral insertion
Viral integration
Sequence mapping
Genome viewer
Online Access:http://link.springer.com/article/10.1186/s12859-017-1837-z

Internet

http://link.springer.com/article/10.1186/s12859-017-1837-z

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