Proinsulin:C-peptide ratio trajectories over time in relatives at increased risk of progression to type 1 diabetes

Objective: Biomarkers are needed to characterize heterogeneity within populations at risk for type 1 diabetes. The ratio of proinsulin to C-peptide (PI:C ratio), has been proposed as a biomarker of beta cell dysfunction and is associated with progression to type 1 diabetes. However, relationships be...

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Bibliographic Details
Main Authors: Taylor M. Triolo, Laura Pyle, Sona Seligova, Liping Yu, Kimber Simmons, Peter Gottlieb, Carmella Evans-Molina, Andrea K. Steck
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Translational Autoimmunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909021000095