A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone

A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone

The skeleton is a preferred homing site for breast cancer metastasis. To date, treatment options for patients with bone metastases are mostly palliative and the disease is still incurable. Indeed, key mechanisms involved in breast cancer osteotropism are still only partially understood due to the la...

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Bibliographic Details
Main Authors: Laure Thibaudeau, Anna V. Taubenberger, Boris M. Holzapfel, Verena M. Quent, Tobias Fuehrmann, Parisa Hesami, Toby D. Brown, Paul D. Dalton, Carl A. Power, Brett G. Hollier, Dietmar W. Hutmacher
Format: Article
Language:English
Published: The Company of Biologists 2014-02-01
Series:Disease Models & Mechanisms
Subjects:
Humanized xenograft model
Bone metastasis
Breast cancer
Osteotropism
Tissue engineering
Melt electrospinning
Online Access:http://dmm.biologists.org/content/7/2/299

Internet

http://dmm.biologists.org/content/7/2/299

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