Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson’s disease

Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson’s disease

Abstract Mutation of the gene PARK7 (DJ1) causes monogenic autosomal recessive Parkinson’s disease (PD) in humans. Subsequent alterations of PARK7 protein function lead to mitochondrial dysfunction, a major element in PD pathology. Homozygous mutants for the PARK7-orthologous genes in zebrafish, par...

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Bibliographic Details
Main Authors: Hui Yung Chin, Michael Lardelli, Lyndsey Collins-Praino, Karissa Barthelson
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Brain
Subjects:
DJ-1
PARK7
Parkinson disease
Zebrafish
RNA-seq
Enrichment analysis
Online Access:https://doi.org/10.1186/s13041-021-00792-9

Internet

https://doi.org/10.1186/s13041-021-00792-9

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