Sphingosine-1-Phosphate: Boon and Bane for the Brain

Sphingosine-1-Phosphate: Boon and Bane for the Brain

Sphingosine-1-phosphate (S1P), an evolutionary conserved bioactive lipid, is essential for brain development, but might also exert detrimental effects in terminally differentiated post-mitotic neurons. Its concentration in the brain is tightly regulated by specific kinases and phosphatases, and main...

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Bibliographic Details
Main Authors: Gerhild van Echten-Deckert, Nadine Hagen-Euteneuer, Ilker Karaca, Jochen Walter
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Sphingosine-1-phosphate
S1P-lyase
Neurodegeneration
Amyloid beta
cis-4-methylsphingosine
FTY720 (fingolimod)
Alzheimer’s disease
Tau
Online Access:http://www.karger.com/Article/FullText/362991

Internet

http://www.karger.com/Article/FullText/362991

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