Inflammatory priming enhances mesenchymal stromal cell secretome potential as a clinical product for regenerative medicine approaches through secreted factors and EV-miRNAs: the example of joint disease

Inflammatory priming enhances mesenchymal stromal cell secretome potential as a clinical product for regenerative medicine approaches through secreted factors and EV-miRNAs: the example of joint disease

Abstract Background Mesenchymal stromal cell (MSC)-enriched products showed positive clinical outcomes in regenerative medicine, where tissue restoration and inflammation control are needed. GMP-expanded MSCs displayed an even higher potential due to exclusive secretion of therapeutic factors, both...

Full description

Bibliographic Details
Main Authors: Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca, Carlotta Mondadori, Marco Viganò, Alessandra Colombini, Laura de Girolamo
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stromal cells
Adipose tissue
Secreted factors
miRNAs
Secretome
Osteoarthritis
Online Access:http://link.springer.com/article/10.1186/s13287-020-01677-9

Internet

http://link.springer.com/article/10.1186/s13287-020-01677-9

Similar Items