Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABAA receptors

Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABAA receptors

Summary: GABA can depolarize immature neurons close to the action potential (AP) threshold in development and adult neurogenesis. Nevertheless, GABAergic synapses effectively inhibit AP firing in newborn granule cells of the adult hippocampus as early as two weeks post-mitosis. The underlying mechan...

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Bibliographic Details
Main Authors: Meredith Lodge, Maria-Clemencia Hernandez, Jan M. Schulz, Josef Bischofberger
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
adult neurogenesis
α5-GABAA receptors
hippocampus
granule cells
GABA receptors
NMDA receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721012225

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721012225

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