The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology

The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology

Dysfunction of nerve growth factor (NGF) and its high-affinity Tropomyosin receptor kinase A (TrkA) receptor has been suggested to contribute to the selective degeneration of basal forebrain cholinergic neurons (BFCN) associated with the progressive cognitive decline in Alzheimer's disease (AD)...

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Bibliographic Details
Main Authors: Nadia Canu, Giuseppina Amadoro, Viviana Triaca, Valentina Latina, Valentina Sposato, Veronica Corsetti, Cinzia Severini, Maria Teresa Ciotti, Pietro Calissano
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:International Journal of Molecular Sciences
Subjects:
nerve growth factor (NGF)
Tropomyosin receptor kinase A (TrkA) receptor
basal forebrain cholinergic neurons (BFCN)
Amyloid Precursor Protein (APP)
synapses
tau protein
Alzheimer’s disease (AD)
Online Access:http://www.mdpi.com/1422-0067/18/6/1319

Internet

http://www.mdpi.com/1422-0067/18/6/1319

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