Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of actions⃞

Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of actions⃞

We have identified a series of potent cholesteryl ester transfer protein (CETP) inhibitors, one member of which, torcetrapib, is undergoing phase 3 clinical trials. In this report, we demonstrate that these inhibitors bind specifically to CETP with 1:1 stoichiometry and block both neutral lipid and...

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Bibliographic Details
Main Authors: Ronald W. Clark, Roger B. Ruggeri, David Cunningham, Mark J. Bamberger
Format: Article
Language:English
Published: Elsevier 2006-03-01
Series:Journal of Lipid Research
Subjects:
lipid transfer
high density lipoprotein
atherosclerosis
cardiovascular disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520336087

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http://www.sciencedirect.com/science/article/pii/S0022227520336087

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