Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.

Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.

BACKGROUND: Host T-cell responses are associated with favorable outcomes in epithelial ovarian cancer (EOC), but it remains unclear how best to promote these responses in patients. Toward this goal, we evaluated a panel of clinically relevant cytokines for the ability to enhance multiple T-cell effe...

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Bibliographic Details
Main Authors: Eric Tran, Julie S Nielsen, Darin A Wick, Alvin V Ng, Lisa D S Johnson, Nancy J Nesslinger, Elissa McMurtrie, John R Webb, Brad H Nelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3008736?pdf=render

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http://europepmc.org/articles/PMC3008736?pdf=render

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