Matrine attenuates heterotopic ossification by suppressing TGF-β induced mesenchymal stromal cell migration and osteogenic differentiation

Matrine attenuates heterotopic ossification by suppressing TGF-β induced mesenchymal stromal cell migration and osteogenic differentiation

Purpose of the study: Heterotopic ossification (HO) is a debilitating disease characterized by extraskeletal bone formation. Active TGF-β recruits mesenchymal stromal cells (MSCs), which contribute to trauma-induced HO. Inhibiting TGF-β induced MSC migration and osteogenic differentiation could be a...

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Bibliographic Details
Main Authors: Dong Mao, Xiaoyun Pan, Yongjun Rui, Fengfeng Li
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Matrine
Heterotopic ossification
TGF-β
Osteogenic differentiation
Mesenchymal stromal cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220303449

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http://www.sciencedirect.com/science/article/pii/S0753332220303449

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