Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humans

Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humans

To elucidate the role of innate responses in vaccine immunogenicity, we compared early responses to hepatitis B virus (HBV) surface antigen (HBsAg) combined with different Adjuvant Systems (AS) in healthy HBV-naïve adults, and included these parameters in multi-parametric models of adaptive response...

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Bibliographic Details
Main Authors: Wivine Burny, Andrea Callegaro, Viviane Bechtold, Frédéric Clement, Sophie Delhaye, Laurence Fissette, Michel Janssens, Geert Leroux-Roels, Arnaud Marchant, Robert A. van den Berg, Nathalie Garçon, Robbert van der Most, Arnaud M. Didierlaurent, On Behalf of the ECR-002 Study Group, Isabelle Carletti, Arnaud Didierlaurent, Meral Esen, Julian Gabor, Edwige Haelterman, Caroline Hervé, Yves Horsmans, Peter Kremsner, Philippe Moris, Tino F Schwarz, Fernanda Tavares da Silva, Pascale Van Belle, Pierre Van Damme, Dirk Zuchner
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
vaccine adjuvants
AS01
AS03
AS04
innate immune response
adaptive immune response
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00943/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00943/full

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