Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression.

Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression.

Nonsense suppression therapy is an approach to treat genetic diseases caused by nonsense mutations. This therapeutic strategy pharmacologically suppresses translation termination at Premature Termination Codons (PTCs) in order to restore expression of functional protein. However, the process of Nons...

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Bibliographic Details
Main Authors: Kim M Keeling, Dan Wang, Yanying Dai, Srinivasan Murugesan, Balachandra Chenna, Jeremy Clark, Valery Belakhov, Jeyakumar Kandasamy, Sadanandan E Velu, Timor Baasov, David M Bedwell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3622682?pdf=render

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http://europepmc.org/articles/PMC3622682?pdf=render

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