Polymorphisms in XPD gene could predict clinical outcome of platinum-based chemotherapy for non-small cell lung cancer patients: a meta-analysis of 24 studies.

Polymorphisms in XPD gene could predict clinical outcome of platinum-based chemotherapy for non-small cell lung cancer patients: a meta-analysis of 24 studies.

OBJECTIVE: Xeroderma pigmentosum group D (XPD) is an essential gene involved in the nucleotide excision repair (NER) pathway. Two commonly studied single nucleotide polymorphisms (SNPs) of XPD (Lys751Gln, A>C, rs13181; Asp312Asn, G>A, rs1799793) are implicated in the modulation of DNA repair c...

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Main Authors: Qin Qin, Chi Zhang, Xi Yang, Hongcheng Zhu, Baixia Yang, Jing Cai, Hongyan Cheng, Jianxin Ma, Jing Lu, Liangliang Zhan, Jia Liu, Zheming Liu, Liping Xu, Xinchen Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3829883?pdf=render

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http://europepmc.org/articles/PMC3829883?pdf=render

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