Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome

Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome

The NLRP3 inflammasome is a multiprotein complex that plays a key role in the innate immune system, and aberrant activation of this complex is involved in the pathogenesis of inflammatory diseases. Carvedilol (CVL) is an α-, β-blocker used to treat high blood pressure and congestive heart failure; h...

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Bibliographic Details
Main Authors: Wei-Ting Wong, Lan-Hui Li, Yerra Koteswara Rao, Shih-Ping Yang, Shu-Meng Cheng, Wen-Yu Lin, Cheng-Chung Cheng, Ann Chen, Kuo-Feng Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
Carvedilol
NLRP3 inflammasome
autophagy
mitochondria
peritonitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01920/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01920/full

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