Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for large-scale production of functional human lactoferrin.

Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for large-scale production of functional human lactoferrin.

Large-scale production of biopharmaceuticals by current bioreactor techniques is limited by low transgenic efficiency and low expression of foreign proteins. In general, a bacterial artificial chromosome (BAC) harboring most regulatory elements is capable of overcoming the limitations, but transferr...

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Bibliographic Details
Main Authors: Penghua Yang, Jianwu Wang, Guochun Gong, Xiuzhu Sun, Ran Zhang, Zhuo Du, Ying Liu, Rong Li, Fangrong Ding, Bo Tang, Yunping Dai, Ning Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2565487?pdf=render

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http://europepmc.org/articles/PMC2565487?pdf=render

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