APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.

Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related decline of brain structures and function. Here we use RNA-seq in combination with high resolution histological analyses to show that aging...

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Bibliographic Details
Main Authors: Ileana Soto, Leah C Graham, Hannah J Richter, Stephen N Simeone, Jake E Radell, Weronika Grabowska, W Keith Funkhouser, Megan C Howell, Gareth R Howell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4626092?pdf=render