Vortioxetine Improves Context Discrimination in Mice Through a Neurogenesis Independent Mechanism

Vortioxetine Improves Context Discrimination in Mice Through a Neurogenesis Independent Mechanism

Major Depressive Disorders (MDD) patients may exhibit cognitive deficits and it is currently unclear to which degree treatment with antidepressants may affect cognitive function. Preclinical and clinical observations showed that vortioxetine (VORT, an antidepressant with multimodal activity), presen...

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Bibliographic Details
Main Authors: Daniela Felice, Jean-Philippe Guilloux, Alan Pehrson, Yan Li, Indira Mendez-David, Alain M. Gardier, Connie Sanchez, Denis J. David
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
vortioxetine
context discrimination
neurogenesis
c-Fos
mice
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00204/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00204/full

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