PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy

Synovial sarcoma expresses multiple cancer testis antigens that could potentially be targeted by T-cell receptor (TCR) gene therapy. In this study we investigated whether PRAME-TCR-gene therapy could be an effective treatment for synovial sarcoma by investigating the potential of PRAME-specific T-ce...

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Bibliographic Details
Main Authors: Sietse J Luk, Dirk M van der Steen, Renate S Hagedoorn, Ekaterina S Jordanova, Marco W Schilham, Judith VMG Bovée, Arjen HG Cleven, JH Frederik Falkenburg, Karoly Szuhai, Mirjam HM Heemskerk
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:OncoImmunology
Subjects:
synovial sarcoma
hla class i
prame
t-cell infiltration
tcr-gene therapy
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1507600

Internet

http://dx.doi.org/10.1080/2162402X.2018.1507600

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