Group II intron-based gene targeting reactions in eukaryotes.

Group II intron-based gene targeting reactions in eukaryotes.

Mobile group II introns insert site-specifically into DNA target sites by a mechanism termed retrohoming in which the excised intron RNA reverse splices into a DNA strand and is reverse transcribed by the intron-encoded protein. Retrohoming is mediated by a ribonucleoprotein particle that contains t...

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Bibliographic Details
Main Authors: Marta Mastroianni, Kazuo Watanabe, Travis B White, Fanglei Zhuang, Jamie Vernon, Manabu Matsuura, John Wallingford, Alan M Lambowitz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2518211?pdf=render

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http://europepmc.org/articles/PMC2518211?pdf=render

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