Cardiac-Specific Activation of IKK2 Leads to Defects in Heart Development and Embryonic Lethality.

The transcription factor NF-κB has been associated with a range of pathological conditions of the heart, mainly based on its function as a master regulator of inflammation and pro-survival factor. Here, we addressed the question what effects activation of NF-κB can have during murine heart developme...

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Bibliographic Details
Main Authors: Bärbel Kraut, Harald J Maier, Enikö Kókai, Katja Fiedler, Thomas Boettger, Annett Illing, Sawa Kostin, Paul Walther, Thomas Braun, Thomas Wirth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4634958?pdf=render