Analysis of Lymphocytic DNA Damage in Early Multiple Sclerosis by Automated Gamma-H2AX and 53BP1 Foci Detection: A Case Control Study.

Analysis of Lymphocytic DNA Damage in Early Multiple Sclerosis by Automated Gamma-H2AX and 53BP1 Foci Detection: A Case Control Study.

BACKGROUND:In response to DNA double-strand breaks, the histone protein H2AX becomes phosphorylated at its C-terminal serine 139 residue, referred to as γ-H2AX. Formation of γ-H2AX foci is associated with recruitment of p53-binding protein 1 (53BP1), a regulator of the cellular response to DNA doubl...

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Bibliographic Details
Main Authors: Ludwig Rasche, Lisa Heiserich, Janina Ruth Behrens, Klaus Lenz, Catherina Pfuhl, Katharina Wakonig, René Markus Gieß, Erik Freitag, Caroline Eberle, Jens Wuerfel, Jan Dörr, Peter Bauer, Judith Bellmann-Strobl, Friedemann Paul, Dirk Roggenbuck, Klemens Ruprecht
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4731473?pdf=render

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http://europepmc.org/articles/PMC4731473?pdf=render

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