Mapping the Intramolecular Communications among Different Glutamate Dehydrogenase States Using Molecular Dynamics

Mapping the Intramolecular Communications among Different Glutamate Dehydrogenase States Using Molecular Dynamics

Glutamate dehydrogenase (GDH) is a ubiquitous enzyme that catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate. It acts as an important branch-point enzyme between carbon and nitrogen metabolisms. Due to the multifaceted roles of GDH in cancer, hyperinsulinism/hyperammonemi...

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Bibliographic Details
Main Authors: Shaherin Basith, Balachandran Manavalan, Tae Hwan Shin, Gwang Lee
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomolecules
Subjects:
glutamate dehydrogenase
enzyme
molecular dynamics
network analysis
allostery
regulation
Online Access:https://www.mdpi.com/2218-273X/11/6/798

Internet

https://www.mdpi.com/2218-273X/11/6/798

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