Mapping the Intramolecular Communications among Different Glutamate Dehydrogenase States Using Molecular Dynamics

Mapping the Intramolecular Communications among Different Glutamate Dehydrogenase States Using Molecular Dynamics

Glutamate dehydrogenase (GDH) is a ubiquitous enzyme that catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate. It acts as an important branch-point enzyme between carbon and nitrogen metabolisms. Due to the multifaceted roles of GDH in cancer, hyperinsulinism/hyperammonemi...

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Bibliographic Details
Main Authors:	Shaherin Basith, Balachandran Manavalan, Tae Hwan Shin, Gwang Lee
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Biomolecules
Subjects:	glutamate dehydrogenase enzyme molecular dynamics network analysis allostery regulation
Online Access:	https://www.mdpi.com/2218-273X/11/6/798

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