Beyond <i>BRCA1</i> and <i>BRCA2</i>: Deleterious Variants in DNA Repair Pathway Genes in Italian Families with Breast/Ovarian and Pancreatic Cancers

Beyond <i>BRCA1</i> and <i>BRCA2</i>: Deleterious Variants in DNA Repair Pathway Genes in Italian Families with Breast/Ovarian and Pancreatic Cancers

The 5–10% of breast/ovarian cancers (BC and OC) are inherited, and germline pathogenic (P) variants in DNA damage repair (DDR) genes <i>BRCA1</i> and <i>BRCA2</i> explain only 10–20% of these cases. Currently, new DDR genes have been related to BC/OC and to pancreatic (PC) ca...

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Bibliographic Details
Main Authors: Aldo Germani, Simona Petrucci, Laura De Marchis, Fabio Libi, Camilla Savio, Claudio Amanti, Adriana Bonifacino, Barbara Campanella, Carlo Capalbo, Augusto Lombardi, Stefano Maggi, Mauro Mattei, Mattia Falchetto Osti, Patrizia Pellegrini, Annarita Speranza, Gianluca Stanzani, Valeria Vitale, Antonio Pizzuti, Maria Rosaria Torrisi, Maria Piane
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Journal of Clinical Medicine
Subjects:
hereditary breast/ovarian cancer
pancreatic cancer
next-generation sequencing
gene panel
DNA repair genes
Online Access:https://www.mdpi.com/2077-0383/9/9/3003

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https://www.mdpi.com/2077-0383/9/9/3003

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