Transcriptome Analysis of Circulating Immune Cell Subsets Highlight the Role of Monocytes in Zaire Ebola Virus Makona Pathogenesis

Transcriptome Analysis of Circulating Immune Cell Subsets Highlight the Role of Monocytes in Zaire Ebola Virus Makona Pathogenesis

Existing models of Ebola virus disease (EVD) suggest antigen-presenting cells are initial targets of Zaire ebolavirus (ZEBOV). In vitro studies have shown that ZEBOV infection of monocytes and macrophages results in the production of inflammatory mediators, which may cause lymphocyte apoptosis. Howe...

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Bibliographic Details
Main Authors: Andrea R. Menicucci, Krista Versteeg, Courtney Woolsey, Chad E. Mire, Joan B. Geisbert, Robert W. Cross, Krystle N. Agans, Allen Jankeel, Thomas W. Geisbert, Ilhem Messaoudi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
Ebola
hemorrhagic fever
pathogenesis
RNASeq
monocytes
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01372/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01372/full

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