Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.

Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.

Blood-vessel dysfunction arises before overt hyperglycemia in type-2 diabetes (T2DM). We hypothesised that a metabolomic approach might identify metabolites/pathways perturbed in this pre-hyperglycemic phase. To test this hypothesis and for specific metabolite hypothesis generation, serum metabolic...

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Bibliographic Details
Main Authors: Simon G Anderson, Warwick B Dunn, Moulinath Banerjee, Marie Brown, David I Broadhurst, Royston Goodacre, Garth J S Cooper, Douglas B Kell, J Kennedy Cruickshank
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4153569?pdf=render

Internet

http://europepmc.org/articles/PMC4153569?pdf=render

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