p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

How cancer cells respond to nutrient deprivation remains poorly understood. In certain cancer cells, deprivation of cystine induces a non-apoptotic, iron-dependent form of cell death termed ferroptosis. Recent evidence suggests that ferroptosis sensitivity may be modulated by the stress-responsive t...

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Bibliographic Details
Main Authors: Amy Tarangelo, Leslie Magtanong, Kathryn T. Bieging-Rolett, Yang Li, Jiangbin Ye, Laura D. Attardi, Scott J. Dixon
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
p53
cell death
metabolism
cancer
ferroptosis
reactive oxygen species
glutathione
cystine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319149

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http://www.sciencedirect.com/science/article/pii/S2211124717319149

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