Dynamics and Determinants of Pneumococcal Antibodies Specific against 13 Vaccine Serotypes in the Pre-Vaccination Era.

Introduction of pneumococcal conjugate vaccines (PCVs) for infants decreased overall invasive pneumococcal disease (IPD), while non-vaccine serotype IPD increased. To fully understand this serotype replacement, knowledge about serotype dynamics in the pre-vaccine era is needed. In addition to IPD su...

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Main Authors: Annemarijn C Prins-van Ginkel, Guy A M Berbers, Lucienne H Grundeken, Irina Tcherniaeva, Jelle I Wittenberns, Karin Elberse, Liesbeth Mollema, Hester E de Melker, Mirjam J Knol
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4721864?pdf=render