An Integrated Approach toward NanoBRET Tracers for Analysis of GPCR Ligand Engagement

An Integrated Approach toward NanoBRET Tracers for Analysis of GPCR Ligand Engagement

Gaining insight into the pharmacology of ligand engagement with G-protein coupled receptors (GPCRs) under biologically relevant conditions is vital to both drug discovery and basic research. NanoLuc-based bioluminescence resonance energy transfer (NanoBRET) monitoring competitive binding between flu...

Full description

Bibliographic Details
Main Authors: Michael P. Killoran, Sergiy Levin, Michelle E. Boursier, Kristopher Zimmerman, Robin Hurst, Mary P. Hall, Thomas Machleidt, Thomas A. Kirkland, Rachel Friedman Ohana
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
GPCRS
ligand-engagement
NanoBRET
HiBiT
in silico screen
Online Access:https://www.mdpi.com/1420-3049/26/10/2857

Internet

https://www.mdpi.com/1420-3049/26/10/2857

Similar Items