Critical Role for the Protons in FRTL-5 Thyroid Cells: Nuclear Sphingomyelinase Induced-Damage

Critical Role for the Protons in FRTL-5 Thyroid Cells: Nuclear Sphingomyelinase Induced-Damage

Proliferating thyroid cells are more sensitive to UV-C radiations than quiescent cells. The effect is mediated by nuclear phosphatidylcholine and sphingomyelin metabolism. It was demonstrated that proton beams arrest cell growth and stimulate apoptosis but until now there have been no indications in...

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Bibliographic Details
Main Authors: Elisabetta Albi, Giuseppina Perrella, Andrea Lazzarini, Samuela Cataldi, Remo Lazzarini, Alessandro Floridi, Francesco Saverio Ambesi-Impiombato, Francesco Curcio
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:International Journal of Molecular Sciences
Subjects:
protons
thyroid cells
sphingomyelin
neutral-sphingomyelinase
apoptosis
sphingomyelin-synthase
Online Access:http://www.mdpi.com/1422-0067/15/7/11555

Internet

http://www.mdpi.com/1422-0067/15/7/11555

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