High-Throughput Sequencing of the Expressed Torafugu (Takifugu rubripes) Antibody Sequences Distinguishes IgM and IgT Repertoires and Reveals Evidence of Convergent Evolution

High-Throughput Sequencing of the Expressed Torafugu (Takifugu rubripes) Antibody Sequences Distinguishes IgM and IgT Repertoires and Reveals Evidence of Convergent Evolution

B-cell antigen receptor (BCR) or antibody diversity arises from somatic recombination of immunoglobulin (Ig) gene segments and is concentrated within the Ig heavy (H) chain complementarity-determining region 3 (CDR-H3). We performed high-throughput sequencing of the expressed antibody heavy-chain re...

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Bibliographic Details
Main Authors: Xi Fu, Jianqiang Sun, Engkong Tan, Kentaro Shimizu, Md Shaheed Reza, Shugo Watabe, Shuichi Asakawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
antibody repertoire
heavy (H) chain complementarity-determining region 3
teleost fish
convergent evolution
IgM
IgT
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00251/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00251/full

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