Melatonin Increases Bone Mass around the Prostheses of OVX Rats by Ameliorating Mitochondrial Oxidative Stress via the SIRT3/SOD2 Signaling Pathway

Melatonin Increases Bone Mass around the Prostheses of OVX Rats by Ameliorating Mitochondrial Oxidative Stress via the SIRT3/SOD2 Signaling Pathway

Bone mass loss around prostheses is a major cause of implant failure, especially in postmenopausal osteoporosis patients. In osteoporosis, excess oxidative stress largely contributed abnormal bone remodeling. Melatonin, which is synthesized from the pineal gland, promotes osteoblast differentiation...

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Bibliographic Details
Main Authors: Wei Zhou, Yu Liu, Jining Shen, Binqing Yu, Jiaxiang Bai, Jiayi Lin, Xiaobin Guo, Houyi Sun, Zhanghuan Chen, Huilin Yang, Yaozeng Xu, Dechun Geng
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2019/4019619

Internet

http://dx.doi.org/10.1155/2019/4019619

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