Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults

Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults

Glutamate release is a root cause of acute and delayed neuronal damage in response to hypoxic/ischemic insults. Nevertheless, therapeutics that target the postsynaptic compartment have been disappointing clinically. Here we explored whether presynaptic silencing (muting) of glutamatergic terminals i...

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Bibliographic Details
Main Authors: Joshua Hogins, Devon C. Crawford, Xiaoping Jiang, Steven Mennerick
Format: Article
Language:English
Published: Elsevier 2011-08-01
Series:Neurobiology of Disease
Subjects:
Synaptic plasticity
Glutamate
Hippocampus
Ischemia
Homeostasis
Excitotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001598

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http://www.sciencedirect.com/science/article/pii/S0969996111001598

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