FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer

FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer

Fibroblast growth factor receptor 4 (FGFR4), one of four tyrosine kinase receptors for FGFs, is involved in diverse cellular processes. Activation of FGF19/FGFR4 signaling is closely associated with cancer development and progression. In this study, we examined the expression and roles of FGF19/FGFR...

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Bibliographic Details
Main Authors: Norihiko Sasaki, Fujiya Gomi, Hisashi Yoshimura, Masami Yamamoto, Yoko Matsuda, Masaki Michishita, Hitoshi Hatakeyama, Yoichi Kawano, Masashi Toyoda, Murray Korc, Toshiyuki Ishiwata
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
FGFR4
pancreatic cancer
FGFR4 inhibitor
growth
invasion
senescence
Online Access:https://www.mdpi.com/2072-6694/12/10/2976

Internet

https://www.mdpi.com/2072-6694/12/10/2976

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