Neuropathic Injury–Induced Plasticity of GABAergic System in Peripheral Sensory Ganglia

Neuropathic Injury–Induced Plasticity of GABAergic System in Peripheral Sensory Ganglia

GABA is a major inhibitory neurotransmitter in the mammalian central nervous system (CNS). Inhibitory GABAA channel circuits in the dorsal spinal cord are the gatekeepers of the nociceptive input from the periphery to the CNS. Weakening of these spinal inhibitory mechanisms is a hallmark of chronic...

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Bibliographic Details
Main Authors: Caixue Wang, Han Hao, Kaitong He, Yating An, Zeyao Pu, Nikita Gamper, Hailin Zhang, Xiaona Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
GABAA channel
DRG
neuropathic pain
α5 subunit
plasticity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.702218/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.702218/full

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