The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

The CD40–CD40L dyad is an immune checkpoint regulator that promotes both innate and adaptive immune responses and has therefore an essential role in the development of inflammatory diseases, including multiple sclerosis (MS). In MS, CD40 and CD40L are expressed on immune cells present in blood and l...

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Bibliographic Details
Main Authors: Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Koos J. F. van Dorst, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
CD40
CD40L
multiple sclerosis
experimental autoimmune encephalomyelitis
inflammation
tumor necrosis factor receptor-associated factors
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01791/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01791/full

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