Diabetic Endothelial Cells Differentiated From Patient iPSCs Show Dysregulated Glycine Homeostasis and Senescence Associated Phenotypes

Diabetic Endothelial Cells Differentiated From Patient iPSCs Show Dysregulated Glycine Homeostasis and Senescence Associated Phenotypes

Induced pluripotent stem cells derived cells (iPSCs) not only can be used for personalized cell transfer therapy, but also can be used for modeling diseases for drug screening and discovery in vitro. Although prior studies have characterized the function of rodent iPSCs derived endothelial cells (EC...

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Bibliographic Details
Main Authors: Liping Su, Xiaocen Kong, Sze Jie Loo, Yu Gao, Jean-Paul Kovalik, Xiaofei Su, Jianhua Ma, Lei Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
endothelium
endothelial function
senescence
mitochondrial function
glycine
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.667252/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.667252/full

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