Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks

Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks

Abstract Background Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response. Methods Using network analysis, we defined the spatiotemporal dynamics of 20, LPS-induced, protein-level inflammatory mediators over 0–48 h in the heart, g...

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Bibliographic Details
Main Authors: Ruben Zamora, Sangeeta Chavan, Theodoros Zanos, Richard L. Simmons, Timothy R. Billiar, Yoram Vodovotz
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Medicine
Subjects:
Endotoxemia
Endotoxin
Lipopolysaccharide
TLR4
Cytokines
Chemokines
Online Access:https://doi.org/10.1186/s10020-021-00333-z

Internet

https://doi.org/10.1186/s10020-021-00333-z

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