Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice
G Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detrimental FPR signalling, showing beneficial therape...
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2017-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms14232 |
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doaj-662689059cf2432b82994c3add7656fb2021-05-11T07:51:25ZengNature Publishing GroupNature Communications2041-17232017-02-018111310.1038/ncomms14232Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in miceCheng Xue Qin0Lauren T. May1Renming Li2Nga Cao3Sarah Rosli4Minh Deo5Amy E. Alexander6Duncan Horlock7Jane E. Bourke8Yuan H. Yang9Alastair G. Stewart10David M. Kaye11Xiao-Jun Du12Patrick M. Sexton13Arthur Christopoulos14Xiao-Ming Gao15Rebecca H. Ritchie16Baker IDI Heart and Diabetes InstituteDepartment of Pharmacology, Division of Drug Discovery Biology, Department of Pharmacology, Monash UniversityBaker IDI Heart and Diabetes InstituteBaker IDI Heart and Diabetes InstituteBaker IDI Heart and Diabetes InstituteBaker IDI Heart and Diabetes InstituteBaker IDI Heart and Diabetes InstituteBaker IDI Heart and Diabetes InstituteDepartment of Pharmacology, Monash UniversityCentre of Inflammatory Diseases, Monash UniversityDepartment of Pharmacology, University of MelbourneBaker IDI Heart and Diabetes InstituteBaker IDI Heart and Diabetes InstituteDepartment of Pharmacology, Division of Drug Discovery Biology, Department of Pharmacology, Monash UniversityDepartment of Pharmacology, Division of Drug Discovery Biology, Department of Pharmacology, Monash UniversityBaker IDI Heart and Diabetes InstituteBaker IDI Heart and Diabetes InstituteG Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detrimental FPR signalling, showing beneficial therapeutic effect in a mouse model of cardiac infarction.https://doi.org/10.1038/ncomms14232 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng Xue Qin Lauren T. May Renming Li Nga Cao Sarah Rosli Minh Deo Amy E. Alexander Duncan Horlock Jane E. Bourke Yuan H. Yang Alastair G. Stewart David M. Kaye Xiao-Jun Du Patrick M. Sexton Arthur Christopoulos Xiao-Ming Gao Rebecca H. Ritchie |
spellingShingle |
Cheng Xue Qin Lauren T. May Renming Li Nga Cao Sarah Rosli Minh Deo Amy E. Alexander Duncan Horlock Jane E. Bourke Yuan H. Yang Alastair G. Stewart David M. Kaye Xiao-Jun Du Patrick M. Sexton Arthur Christopoulos Xiao-Ming Gao Rebecca H. Ritchie Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice Nature Communications |
author_facet |
Cheng Xue Qin Lauren T. May Renming Li Nga Cao Sarah Rosli Minh Deo Amy E. Alexander Duncan Horlock Jane E. Bourke Yuan H. Yang Alastair G. Stewart David M. Kaye Xiao-Jun Du Patrick M. Sexton Arthur Christopoulos Xiao-Ming Gao Rebecca H. Ritchie |
author_sort |
Cheng Xue Qin |
title |
Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice |
title_short |
Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice |
title_full |
Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice |
title_fullStr |
Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice |
title_full_unstemmed |
Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice |
title_sort |
small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-02-01 |
description |
G Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detrimental FPR signalling, showing beneficial therapeutic effect in a mouse model of cardiac infarction. |
url |
https://doi.org/10.1038/ncomms14232 |
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