The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

Abstract Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions. This signaling involves close physical contacts between the two organelles that are mediated by “tethering proteins” that function to recruit regions of ER to the mitochondrial su...

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Bibliographic Details
Main Authors: Patricia Gómez-Suaga, Beatriz G. Pérez-Nievas, Elizabeth B. Glennon, Dawn H. W. Lau, Sebastien Paillusson, Gábor M. Mórotz, Tito Calì, Paola Pizzo, Wendy Noble, Christopher C. J. Miller
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Acta Neuropathologica Communications
Subjects:
VAPB
PTPIP51
Endoplasmic reticulum
Mitochondria
Parkinson’s disease
Frontotemporal dementia
Online Access:http://link.springer.com/article/10.1186/s40478-019-0688-4

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http://link.springer.com/article/10.1186/s40478-019-0688-4

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