Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator

Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator

Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia. Pharmacological management of arrhythmia associated with QT prolongation is...

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Bibliographic Details
Main Authors: Michael A. Colman, Erick A. Perez Alday, Arun V. Holden, Alan P. Benson
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Physiology
Subjects:
QT interval
action potential duration
arrhythmia trigger
arrhythmia substrate
hERG activators
computational modeling
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00757/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00757/full

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