Development of a Positive-readout Mouse Model of siRNA Pharmacodynamics

Development of RNAi-based therapeutics has the potential to revolutionize treatment options for a range of human diseases. However, as with gene therapy, a major barrier to progress is the lack of methods to achieve and measure efficient delivery for systemic administration. We have developed a posi...

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Bibliographic Details
Main Authors: Mark Stevenson, Robert Carlisle, Ben Davies, Chris Preece, Michelle Hammett, Wei-li Liu, Kerry David Fisher, Amy Ryan, Heidi Scrable, Leonard William Seymour
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301949