Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically*

Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically*

Glucocorticoids (GCs) increase hepatic phosphatidate phosphatase (PAP1) activity. This is important in enhancing the liver's capacity for storing fatty acids as triacylglycerols (TAGs) that can be used subsequently for β-oxidation or VLDL secretion. PAP1 catalyzes the conversion of phosphatidat...

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Bibliographic Details
Main Authors: Boripont Manmontri, Meltem Sariahmetoglu, Jimmy Donkor, Maroun Bou Khalil, Meenakshi Sundaram, Zemin Yao, Karen Reue, Richard Lehner, David N. Brindley
Format: Article
Language:English
Published: Elsevier 2008-05-01
Series:Journal of Lipid Research
Subjects:
β-oxidation
diabetes
ethanol ingestion
fasting
glucagon
hypertriglyceridemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520425933

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http://www.sciencedirect.com/science/article/pii/S0022227520425933

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