Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

The RIG-I-like receptors RIG-I, LGP2, and MDA5 initiate an antiviral response that includes production of type I interferons (IFNs). The nature of the RNAs that trigger MDA5 activation in infected cells remains unclear. Here, we purify and characterise LGP2/RNA complexes from cells infected with enc...

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Bibliographic Details
Main Authors: Safia Deddouche, Delphine Goubau, Jan Rehwinkel, Probir Chakravarty, Sharmin Begum, Pierre V Maillard, Annabel Borg, Nik Matthews, Qian Feng, Frank J M van Kuppeveld, Caetano Reis e Sousa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-02-01
Series:eLife
Subjects:
RIG-I-like receptor
MDA5
LGP2
picornavirus
EMCV
antiviral immunity
Online Access:https://elifesciences.org/articles/01535

Internet

https://elifesciences.org/articles/01535

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