Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8

Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8

The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking. The nociceptive behaviors induced by i.t. treatment wi...

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Bibliographic Details
Main Authors: Takafumi Hayashi, Chizuko Watanabe, Soh Katsuyama, Yasuyuki Agatsuma, Damiana Scuteri, Giacinto Bagetta, Tsukasa Sakurada, Shinobu Sakurada
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
cholecystokinin-8
nociceptive behaviors
histamine
spinal cord
tachykinin neurokinin-1 receptor
N-methyl-D-aspartate receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.590918/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.590918/full

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