Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition

Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition

Increasing evidence suggests that intestinal dysfunctions may represent early events in Alzheimer’s disease and contribute to brain pathology. This study examined the relationship between onset of cognitive impairment and colonic dysfunctions in a spontaneous AD model before the full development of...

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Bibliographic Details
Main Authors: Carolina Pellegrini, Simona Daniele, Luca Antonioli, Laura Benvenuti, Vanessa D’Antongiovanni, Rebecca Piccarducci, Deborah Pietrobono, Valentina Citi, Eugenia Piragine, Lorenzo Flori, Chiara Ippolito, Cristina Segnani, Pablo Palazon-Riquelme, Gloria Lopez-Castejon, Alma Martelli, Rocchina Colucci, Nunzia Bernardini, Maria Letizia Trincavelli, Vincenzo Calderone, Claudia Martini, Corrado Blandizzi, Matteo Fornai
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
mild cognitive impairment
colonic motility
enteric inflammation
NLRP3 inflammasome
interleukin-1β
Online Access:https://www.mdpi.com/1422-0067/21/10/3523

Internet

https://www.mdpi.com/1422-0067/21/10/3523

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