Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders

Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders

Abstract Emerging evidence demonstrates that adaptive immunity influences the pathobiology of neurodegenerative disorders. Misfolded aggregated self-proteins can break immune tolerance leading to the induction of autoreactive effector T cells (Teffs) with associated decreases in anti-inflammatory ne...

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Bibliographic Details
Main Authors: Jatin Machhi, Bhavesh D. Kevadiya, Ijaz Khan Muhammad, Jonathan Herskovitz, Katherine E. Olson, R. Lee Mosley, Howard E. Gendelman
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Neurodegeneration
Subjects:
Regulatory T cells (Tregs)
Effector T cells (Teffs)
Dendritic cells
Microglia
Immune transformation
Neurodegenerative disorders
Online Access:http://link.springer.com/article/10.1186/s13024-020-00375-7

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http://link.springer.com/article/10.1186/s13024-020-00375-7

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